Evekeo vs. Adderall: How Do These ADHD Medications Compare?

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Introduction

Adderall is one of the most widely known medications for ADHD, but it’s not the only amphetamine-based option. Evekeo is another prescription stimulant sometimes used to treat ADHD, and although it’s less commonly prescribed, it may be a better fit for certain individuals.

In this guide, we’ll break down how Evekeo compares to Adderall in terms of ingredients, dosing, side effects, and cost. If you've been prescribed either, you can also explore savings options with a CareCard prescription discount card, accepted at over 80,000 pharmacies nationwide.

Conditions Treated by Stimulants

ADHD and Related Conditions

Both Adderall and Evekeo are FDA-approved to treat ADHD in children and adults. Evekeo is also approved for narcolepsy and exogenous obesity, though the focus here is on its use in ADHD management.

How These Medications Work

Both drugs are stimulants that affect norepinephrine and dopamine levels in the brain. This helps improve focus, reduce impulsivity, and support executive functioning. They’re often prescribed as part of a broader ADHD treatment plan that may include behavioral therapy and daily structure.

What Is Evekeo?

Evekeo contains amphetamine sulfate, which is a single salt form of amphetamine. Unlike Adderall, which combines multiple amphetamine salts, Evekeo contains only one. Some individuals may tolerate it better or respond differently based on this difference.

Duration and Dosage

• Onset: 30 to 60 minutes

• Duration: 4 to 6 hours (immediate-release)

• Available in tablet form only

• Typically dosed 1 to 2 times per day

Common Side Effects

Evekeo may cause:

• Decreased appetite

• Dry mouth

• Irritability

• Increased heart rate

• Sleep disturbances

As with other stimulants, side effects should be monitored and reported to your healthcare provider.

Cost and Access

Evekeo is available in brand-name and generic forms. Pricing varies, but you can compare pharmacy prices and access potential discounts with a CareCard prescription discount card.

What Is Adderall?

Adderall contains a mix of four amphetamine salts: dextroamphetamine and levoamphetamine in equal proportions. This blend may provide a different experience for some patients compared to single-salt formulations like Evekeo.

Duration and Dosage

• Onset: 30 to 60 minutes

• Duration: 4 to 6 hours (immediate-release), up to 12 hours (extended-release)

• Available as tablets (IR) and capsules (XR)

• Dosed once or multiple times daily based on version

Common Side Effects

Adderall may cause:

• Insomnia

• Nervousness

• Loss of appetite

• Increased blood pressure

• Stomach upset

Both medications are Schedule II controlled substances and should only be used as prescribed.

Cost and Access

Generic versions of Adderall are widely available, which may make it more affordable. To lower costs even further, a CareCard prescription discount card can be used at most pharmacies.

Evekeo vs. Adderall Comparison Chart

Key Differences Between Evekeo and Adderall

Salt Composition

Evekeo contains a single type of amphetamine salt, while Adderall contains a combination of four. While both are stimulants, the blend in Adderall may create a different therapeutic profile for some patients.

Dosing and Flexibility

Both are typically short-acting unless Adderall XR is used. Evekeo’s once- or twice-daily dosing may be similar to Adderall IR but does not offer an extended-release form.

Cost and Accessibility

Adderall’s generics are more widely prescribed, which may make it easier to find or fill. Evekeo is less commonly used, and may be more expensive in some cases. Either option may be discounted with a CareCard prescription discount card.

How to Choose Between Evekeo and Adderall

Factors Your Provider May Consider

• Response to other amphetamine medications

• Need for short- vs. long-acting symptom relief

• Coexisting conditions or sensitivities

• Insurance coverage and out-of-pocket costs

• Daily routine and dosing preferences

Individual Trial May Be Necessary

If one medication doesn’t work well or causes side effects, a provider may recommend trying the other. Personal response and tolerability can vary between amphetamine formulations.

Conclusion

Evekeo and Adderall are both stimulant medications used to treat ADHD, but they differ in their salt makeup, duration, and availability. Choosing between them comes down to individual needs, response, and lifestyle fit.

If you’ve been prescribed either medication, you can also explore savings options using a CareCard prescription discount card, accepted at more than 80,000 pharmacies with no insurance required.

Frequently Asked Questions

1. What is the difference between Evekeo and Adderall? Evekeo contains only one type of amphetamine salt (amphetamine sulfate), while Adderall combines four different amphetamine salts. Both treat ADHD, but some people may respond better to one than the other.

2. Which one lasts longer—Evekeo or Adderall? Adderall XR is formulated to last 10–12 hours, while Evekeo is available in immediate- and extended-release forms that may not last as long depending on the dose and formulation.

3. Can I switch from Adderall to Evekeo? Switching medications should only be done under medical supervision. Your doctor can help decide which option best fits your needs.

4. Is Evekeo covered by insurance? Some insurance plans cover Evekeo, but availability and coverage may vary. Generic Adderall may be cheaper depending on your plan or pharmacy.

5. How can I find lower prices on ADHD medications?

You can search the CareCard website or app to instantly compare prices at over 80,000 pharmacies. Just show your prescription discount card at checkout to save—no insurance required.