Jul 07, 2025
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Pain relief is essential for managing various conditions, from headaches to arthritis. Aleve (naproxen sodium) and Tylenol (acetaminophen) are two popular over-the-counter medications used for pain and fever relief. While both drugs provide effective relief, they work differently and are suited for different needs. This article compares Aleve and Tylenol to help you make an informed decision.
Aleve contains naproxen sodium, a nonsteroidal anti-inflammatory drug (NSAID). It is primarily used to reduce pain, inflammation, and fever.
Aleve works by inhibiting the production of prostaglandins, which are substances responsible for pain and inflammation.
Aleve is commonly used to treat:
Arthritis
Muscle pain
Back pain
Headaches
Menstrual cramps
Fever
Common side effects:
Stomach pain
Heartburn
Dizziness
Serious side effects:
Stomach ulcers
Increased risk of heart attack or stroke
Kidney problems
Available in 220 mg tablets.
Typical dosage: 1 tablet every 8-12 hours.
Maximum: 3 tablets in 24 hours.
Aleve can interact with:
Blood thinners (e.g., warfarin)
Other NSAIDs (e.g., ibuprofen)
Blood pressure medications
Alcohol (increases risk of stomach bleeding)
Tylenol contains acetaminophen, a pain reliever and fever reducer that is not an NSAID.
Tylenol blocks pain signals in the brain but does not reduce inflammation.
Tylenol is commonly used to treat:
Headaches
Muscle pain
Arthritis (without inflammation)
Fever
Toothaches
Cold and flu symptoms
Common side effects:
Nausea
Rash (rare)
Serious side effects:
Liver damage (with high doses)
Allergic reactions
Available in 325 mg, 500 mg, and 650 mg tablets.
Typical dosage: 325-650 mg every 4-6 hours.
Maximum: 3,000 mg per day (or 4,000 mg under doctor supervision).
Tylenol can interact with:
Alcohol (increases liver damage risk)
Blood thinners (e.g., warfarin)
Certain antibiotics and seizure medications
Aleve is better for pain caused by inflammation (e.g., arthritis, muscle aches).
Tylenol is better for reducing fever and relieving mild pain without inflammation.
Aleve can cause stomach irritation, ulcers, and heart risks.
Tylenol can cause liver damage if taken in high doses.
Both drugs are available in brand and generic forms.
Generic versions (naproxen sodium and acetaminophen) are usually more affordable.
When choosing between Aleve and Tylenol, consider:
If you need inflammation relief, choose Aleve.
If you have stomach sensitivities, choose Tylenol.
If you need longer-lasting pain relief, choose Aleve.
If you need fever reduction, choose Tylenol.
Always consult your healthcare provider before using either medication, especially if you have underlying health conditions or take other medications.
Aleve and Tylenol are both effective pain relievers, but they serve different purposes. Aleve is better for inflammatory pain, while Tylenol is safer for those with stomach sensitivities or liver concerns. The best choice depends on your specific health needs.
To save on your prescription and over-the-counter medications, consider using a prescription discount card from CareCard.
Can I take Aleve and Tylenol together? Yes, but only under a doctor’s supervision to avoid overdose or interactions.
Which is safer for long-term use? Tylenol is generally safer for long-term use, while Aleve should be used cautiously due to stomach and heart risks.
Can I take Aleve or Tylenol while pregnant? Tylenol is usually considered safer during pregnancy. Consult your doctor before taking Aleve.
Which is better for headaches? Tylenol is typically better for headaches, while Aleve is better for migraines.
Does Aleve last longer than Tylenol? Yes, Aleve lasts 8-12 hours, while Tylenol lasts 4-6 hours.