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Jul 07, 2025

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Aleve vs. Tylenol: Which Pain Reliever is Right for You?

Aleve vs. Tylenol

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Pain relief is essential for managing various conditions, from headaches to arthritis. Aleve (naproxen sodium) and Tylenol (acetaminophen) are two popular over-the-counter medications used for pain and fever relief. While both drugs provide effective relief, they work differently and are suited for different needs. This article compares Aleve and Tylenol to help you make an informed decision.

What is Aleve?

Aleve contains naproxen sodium, a nonsteroidal anti-inflammatory drug (NSAID). It is primarily used to reduce pain, inflammation, and fever.

How Aleve Works

Aleve works by inhibiting the production of prostaglandins, which are substances responsible for pain and inflammation.

Effectiveness of Aleve

Aleve is commonly used to treat:

  • Arthritis

  • Muscle pain

  • Back pain

  • Headaches

  • Menstrual cramps

  • Fever

Side Effects of Aleve

Common side effects:

  • Stomach pain

  • Heartburn

  • Dizziness

Serious side effects:

  • Stomach ulcers

  • Increased risk of heart attack or stroke

  • Kidney problems

Aleve Dosage and Administration

  • Available in 220 mg tablets.

  • Typical dosage: 1 tablet every 8-12 hours.

  • Maximum: 3 tablets in 24 hours.

Aleve Interactions

Aleve can interact with:

  • Blood thinners (e.g., warfarin)

  • Other NSAIDs (e.g., ibuprofen)

  • Blood pressure medications

  • Alcohol (increases risk of stomach bleeding)

Tylenol Overview

What is Tylenol?

Tylenol contains acetaminophen, a pain reliever and fever reducer that is not an NSAID.

How Tylenol Works

Tylenol blocks pain signals in the brain but does not reduce inflammation.

Effectiveness of Tylenol

Tylenol is commonly used to treat:

  • Headaches

  • Muscle pain

  • Arthritis (without inflammation)

  • Fever

  • Toothaches

  • Cold and flu symptoms

Side Effects of Tylenol

Common side effects:

  • Nausea

  • Rash (rare)

Serious side effects:

  • Liver damage (with high doses)

  • Allergic reactions

Tylenol Dosage and Administration

  • Available in 325 mg, 500 mg, and 650 mg tablets.

  • Typical dosage: 325-650 mg every 4-6 hours.

  • Maximum: 3,000 mg per day (or 4,000 mg under doctor supervision).

Tylenol Interactions

Tylenol can interact with:

  • Alcohol (increases liver damage risk)

  • Blood thinners (e.g., warfarin)

  • Certain antibiotics and seizure medications

Aleve and Tylenol

Effectiveness Comparison

  • Aleve is better for pain caused by inflammation (e.g., arthritis, muscle aches).

  • Tylenol is better for reducing fever and relieving mild pain without inflammation.

Side Effects Comparison

  • Aleve can cause stomach irritation, ulcers, and heart risks.

  • Tylenol can cause liver damage if taken in high doses.

Cost Comparison

  • Both drugs are available in brand and generic forms.

  • Generic versions (naproxen sodium and acetaminophen) are usually more affordable.

Choosing Between Aleve and Tylenol

When choosing between Aleve and Tylenol, consider:

  • If you need inflammation relief, choose Aleve.

  • If you have stomach sensitivities, choose Tylenol.

  • If you need longer-lasting pain relief, choose Aleve.

  • If you need fever reduction, choose Tylenol.

Always consult your healthcare provider before using either medication, especially if you have underlying health conditions or take other medications.

Conclusion

Aleve and Tylenol are both effective pain relievers, but they serve different purposes. Aleve is better for inflammatory pain, while Tylenol is safer for those with stomach sensitivities or liver concerns. The best choice depends on your specific health needs.

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FAQs

  1. Can I take Aleve and Tylenol together? Yes, but only under a doctor’s supervision to avoid overdose or interactions.

  2. Which is safer for long-term use? Tylenol is generally safer for long-term use, while Aleve should be used cautiously due to stomach and heart risks.

  3. Can I take Aleve or Tylenol while pregnant? Tylenol is usually considered safer during pregnancy. Consult your doctor before taking Aleve.

  4. Which is better for headaches? Tylenol is typically better for headaches, while Aleve is better for migraines.

Does Aleve last longer than Tylenol? Yes, Aleve lasts 8-12 hours, while Tylenol lasts 4-6 hours.

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